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US 11,999,708 B1Granted
Thiazole tethered organoselenides as 5-lipoxygenase inhibitors
AssigneeKing Faisal University
InventorsSaad Shaaban, Hussein Ba-Ghazal, Mohamed Alaa Mohamed, Abeer M. Ashmawy
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Abstract
Thiazole tethered organoselenide compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The thiazole tethered organoselenide compounds are identified as being capable of inhibiting 5-lipoxygenase (5-LO).
Claims17
A compound having the formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- R is selected from the group consisting of
- methyl, ethyl, butyl, pentyl, and hexyl;
- and
- each X is the same or different and is H or COOMe.
2 more elements
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof;
- wherein X is H or COOMe.
Dependencies are inferred from the claim text.