4,5-bis(4-chlorophenyl)-2-phenyl-1H-imidazol-1-yl as an antimicrobial compound
AssigneeKing Faisal University
InventorsHany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Amer A. Amer, Antar Ahmed Abdelhamid Ahmed
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Abstract
A 4,5-bis(4-chlorophenyl)-2-phenyl-1H-imidazole compound, its synthesis, and its use as an anticancer, anti-inflammatory, and/or antimicrobial agent.
Claims15
A pharmaceutically acceptable composition comprising a therapeutically effective amount of a 4,5-bis(4-chlorophenyl)-2-phenyl-1H-imidazole compound and a pharmaceutically acceptable carrier, the 4,5-bis(4-chlorophenyl)-2-phenyl-1H-imidazole compound having the formula I:
A method of treating a microbial infection in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a 4,5-bis(4-chlorophenyl)-2-phenyl-1H-imidazole compound having the formula I:
A method of making a 4,5-bis(4-chlorophenyl)-2-phenyl-1H-imidazole compound, the method comprising:
- adding 1,2-bis(4-chlorophenyl)ethane-1,2-dione, benzaldehyde, and ammonium acetate to acetic acid to obtain a reaction mixture;
- exposing the reaction mixture to ultrasonic irradiation until reaction completion to obtain a formed precipitate;
- purifying the formed precipitate by recrystallization using ethanol;
- and
- obtaining the 4,5-bis(4-chlorophenyl)-2-phenyl-1H-imidazole compound.
Dependencies are inferred from the claim text.