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US 11,999,696 B2Granted
Heterocyclic azide units and their use in polymer coatings
AssigneeIllumina Cambridge Limited
InventorsWayne N. George, Xiaolin Wu, Andrew A. Brown, Donald Wellings
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Abstract
Described herein are heterocyclic azide-containing monomer units, copolymers comprising such heterocyclic azide-containing monomer units, substrate-bound copolymers, and oligonucleotide-bound copolymers, methods for making such copolymers and reacting them with a substrate and/or oligonucleotide, and methods of using such copolymers for immobilization of oligonucleotides to a substrate, for example for use in DNA sequencing or other diagnostic applications.
Claims20
A compound of formula (I)
- wherein
- R1 is H or C1-4 alkyl;
- R2 is H or C1-4 alkyl;
- L is a linker comprising a linear chain having 2 to 20 atoms selected from the group consisting of carbon, oxygen, and nitrogen and optional substituents on the carbon and any nitrogen atoms in the chain;
- E is a linear chain having 1 to 4 atoms selected from the group consisting of carbon, oxygen and nitrogen, and optional substituents on the carbon and any nitrogen atoms in the chain;
- A is an N substituted amide having formula
- wherein R3 is H or C1-4 alkyl;
- and
- Z is a nitrogen containing heterocycle.
6 more elements
A copolymer comprising a recurring monomer unit of formula (II):
- wherein
- R1 is H or C1-4 alkyl;
- R2 is H or C1-4 alkyl;
- L is a linker comprising a linear chain having 2 to 20 atoms selected from the group consisting of carbon, oxygen, and nitrogen and optional substituents on the carbon and any nitrogen atoms in the chain;
- E is a linear chain having 1 to 4 atoms selected from the group consisting of carbon, oxygen and nitrogen, and optional substituents on the carbon and any nitrogen atoms in the chain;
- A is an N substituted amide having formula
- wherein R3 is H or C1-4 alkyl;
- and
- Z is a nitrogen containing heterocycle;
- and
- at least one other recurring monomer unit.
8 more elements
Dependencies are inferred from the claim text.