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US 11,999,683 B2Granted
Lipocationic dendrimers and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsDaniel J. Siegwart, Kejin Zhou
Life of this patent
Estimating the term…
Abstract
Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
Claims20
A compound that is a compound of Formula (I):
- Core-Repeating Unit-Terminating Group (I),
- or a pharmaceutically acceptable salt thereof, wherein the core is linked to four repeating units and each repeating unit is linked to a nitrogen of the core, wherein the core has the following structure:
- wherein each repeating unit is a degradable diacyl, having the formula
- wherein in Formula (VII),
- A1 and A2 are each —O—;
- Y3 is alkanediyl(C≤12);
- R9 is alkanediyl(C≤8);
- and
- the terminating group is:
- wherein Y4 is alkanediyli(C≤18) and R10 is H.
7 more elements
A compound that is a compound of Formula (I):
- Core-Repeating Unit-Terminating Group (I),
- or a pharmaceutically acceptable salt thereof, wherein the core is linked to four repeating units and each repeating unit is linked to a nitrogen of the core, wherein the core has the following structure:
- wherein the repeating unit is a degradable diacyl, having the formula:
- wherein in Formula (VII),
- A1 and A2 are each —O—;
- Y3 is —CH2CH2—;
- R9 is —CH3;
- and
- the terminating group is:
6 more elements
A compound of Formula (I):
- Core-Repeating Unit-Terminating Group (I),
- wherein the core is linked to four repeating units and each repeating unit is linked to a nitrogen of the core, wherein the core has the following structure:
- wherein the repeating unit is a degradable diacyl, having the formula
- wherein in Formula (VII),
- A1 and A2 are each —O—;
- Y3 is —CH2CH2—;
- R9 is —CH3;
- and
- the terminating group is:
6 more elements
Dependencies are inferred from the claim text.