Benzylamino-oxoethyl benzamide analogs and methods of use
AssigneeThe Board of Regents of the University of Oklahoma
InventorsWeidong Wang, Venkateswararao Eeda
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Abstract
Benzylamino-oxoethyl benzamide compounds for use in treating diseases and conditions associated with abnormal cell function related to endoplasmic reticulum (ER) stress. For example, the compounds can be used as suppressors of ER stress-induced pancreatic β-cell dysfunction and death, for example in the treatment of Type 1 and Type 2 diabetes. The compounds can also be used in treatments for chronic heart disease, neurodegenerative diseases, retinal degeneration, and other metabolic disorders associated with ER stress.
Claims4
A compound having a formula as represented by chemical structure I:
- wherein:
- R=H, Alkyl, or Phenyl;
- R1=H, Me, Cl, F, OMe, OH, or Phenyl;
- R2=H or OH;
- R3=H, NH2, Me, Cl, F, OMe, OH, or Phenyl;
- R4=H or OH;
- R5=H, Me, Cl, F, OMe, or OH;
- R6=H, Me, Cl, F, OMe, OH, CCl3, or CF3;
- R7=H, Me, Cl, F, OMe, OH, or Piperonyl;
- R8=CCl3, CF3, or Piperonyl;
- R9=H, Me, Cl, F, or OMe;
- R10=H, Me, Cl, F, OMe, OH, CCl3, or CF3;
- and
- n=1, and
- wherein one of R2 and R4=H, and one of R2 and R4=OH.
Dependencies are inferred from the claim text.