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US 11,998,908 B2Granted
Preprocessing device, preprocessing method, and non-transitory computer readable medium storing program
AssigneeShimadzu Corporation
InventorHiroshi Iwata
Life of this patent
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Abstract
In a recovery device, a removing target such as a blood cell is removed from a liquid sample in a sample container using a first filter unit, and a microorganism is filtered from the liquid sample using a second filter unit. A controller causes a first switch to block a flow channel in response to a sensor detecting a bubble. A medium flows from a second connection unit of the second filter unit toward a first connection unit. Thus, the microorganism filtered by the second filter unit is recovered by a recovery container together with the medium.
Claims7
A preprocessing device for a liquid sample, the preprocessing device comprising:
- a sample container that accommodates a liquid sample containing a blood cell;
- a first filter unit that includes a first filter for removing the blood cell from the liquid sample in the sample container;
- a second filter unit that includes a second filter, a first connection unit, and a second connection unit, the second filter configured to capture a microorganism that can be contained in the liquid sample, the first connection unit and the second connection unit facing each other with the second filter interposed therebetween, and a bubble point of the second filter being higher than a bubble point of the first filter;
- a first flow channel, a second flow channel, and a third flow channel being formed in the preprocessing device,
- the first flow channel connecting the second filter unit to the sample container and the first filter unit through the first connection unit,
- the first flow channel connecting the second filter unit to a waste liquid recovery unit that receives a waste liquid discharged from the second filter unit, through the second connection unit,
- the second flow channel connecting the second filter unit to a cleaning solution accommodation unit that accommodates a cleaning solution for cleaning the second filter, through the first connection unit,
- the second flow channel connecting the second filter unit to the waste liquid recovery unit through the second connection unit,
- the third flow channel connecting the second filter unit to a recovered liquid accommodation unit that accommodates a recovered liquid for recovering the microorganism captured by the second filter, through the second connection unit, and
- the third flow channel connecting the second filter unit to a recovery unit that accommodates the recovered liquid passing through the second filter unit, through the first connection unit;
- and
- a blocking element configured to block the first flow channel in response to a decrease in a remaining amount of the liquid sample in an upstream position with respect to the second filter unit in the first flow channel.
9 more elements
A preprocessing method comprising:
- removing a removing target from a liquid sample accommodated in a sample container using a first filter and filtering a microorganism from a filtrate of the first filter using a second filter, a bubble point of the second filter being higher than a bubble point of the first filter, the filtering the microorganism including supplying the filtrate of the first filter to one side of the second filter and receiving a waste liquid from another side of the second filter;
- blocking a flow channel between the second filter and the sample container in response to a decrease in a remaining amount of the liquid sample in an upstream position with respect to the second filter in the filtering the microorganism;
- supplying a cleaning solution to the one side of the second filter and receiving a waste liquid from the other side of the second filter to clean the second filter;
- and
- supplying a recovered liquid to the other side of the second filter and receiving the recovered liquid from the one side of the second filter to recover the microorganism from the second filter.
2 more elements
A non-transitory computer-readable medium storing a program executed by a computer to control a preprocessing device including a first filter and a second filter, wherein the computer is programmed to:
- remove a removing target from a liquid sample accommodated in a sample container using the first filter and filter a microorganism from a filtrate of the first filter using the second filter, a bubble point of the second filter being higher than a bubble point of the first filter, the filtering the microorganism including supplying the filtrate of the first filter to one side of the second filter and receiving a waste liquid from an other side of the second filter;
- block a flow channel between the second filter and the sample container in response to a decrease in a remaining amount of the liquid sample in an upstream position with respect to the second filter in the filtering the microorganism;
- supply a cleaning solution to the one side of the second filter and receive a waste liquid from the other side of the second filter to clean the second filter;
- and
- supply a recovered liquid to the other side of the second filter and receive the recovered liquid from the one side of the second filter to recover the microorganism from the second filter.
2 more elements
Dependencies are inferred from the claim text.