Far red and near infrared light-mediated conditioning of tissues and/or blood to prevent reperfusion injury in endovascular therapies

A method for conditioning at least one of tissues or blood to reduce reperfusion injury, the method comprising:

• (a) providing an optical fiber catheter to a region in a subject containing tissues;
• (b) conditioning the at least one of tissues or blood in the region to reduce reperfusion injury by operating a light source coupled to a proximal end of the optical fiber catheter to generate light having at least one wavelength selected from a range of 510 nanometers (nm) to 670 nm, such that the light is communicated from the proximal end of the optical fiber catheter to its distal tip where the light is emitted from the optical fiber catheter and caused to impinge upon the at least one of tissues or blood in the region;
• (c) administering an endovascular therapy to the at least one of tissues or blood in the region;
• and
• wherein the at least one of tissues or blood in the region are conditioned by the light emitted from the optical fiber such that reperfusion injury of the tissues resulting from the endovascular therapy is significantly reduced.