US 11,998,740 B2 · Systems and methods for providing personalized targeted non-invasive stimulation to a brain network

Abstract

Disclosed herein are devices, systems, and methods for ameliorating or treating or preventing Alzheimer's Disease and related dementias. Methods may include using individual patients' data to identify the optimal treatment target(s) as well as the stimulation intensity, frequency, or waveform, or any combination thereof, for transcranial electromagnetic induction delivered via a device as in the case of Transcranial Magnetic Stimulation. Systems and methods include a platform or infrastructure for treatment delivery and data processing. In some embodiments, methods are applied to restore cognitive function, ameliorate clinical symptoms, modify altered mechanisms of plasticity, modulate cortical excitability and reactivity, or induce changes in local brain metabolism.

Claims18

Dependent claims

A method for determining personalized stimulation parameters for non-invasive stimulation of a brain of a subject, the method comprising:

sequentially stimulating using transcranial magnetic stimulation (TMS), each of a plurality of locations within a brain region of the subject, the brain region forming a node of a functional brain network of connected nodes in the brain of the subject;
sensing, using one or more electroencephalography (EEG) electrodes arranged on a scalp of the subject, a plurality of TMS-evoked potentials in response to sequentially stimulating the plurality of locations within the brain region of the subject using TMS;
and
determining, based at least in part on at least one characteristic of the plurality of TMS-evoked potentials, personalized stimulation parameters for the subject, wherein the personalized stimulation parameters include a location of stimulation within the brain region and one or more stimulation characteristics, the one or more stimulation characteristics including a personalized intensity of stimulation.

1 more element

Dependencies are inferred from the claim text.

Systems and methods for providing personalized targeted non-invasive stimulation to a brain network

Life of this patent

Systems and methods for providing personalized targeted non-invasive stimulation to a brain network

Life of this patent

Abstract

Claims18