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US 11,998,675 B2Granted
Systems, assemblies, and methods of trauma management
AssigneeLazarus Technologies LLC
InventorTom Bozzay
Life of this patent
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Abstract
A system for performing extracorporeal blood treatment of recovered blood can include a reservoir to receive a first portion of the recovered blood from a subject, an inline pump coupled the reservoir to regulate a flow rate of at least the first portion of the recovered blood, and an extracorporeal blood conditioner including at least one of an oxygenator to reoxygenate hemoglobin included in the recovered blood for at least intravenous delivery back to the subject or a temperature regulator configured to selectively control a temperature of the recovered blood.
Claims15
A device for performing extracorporeal blood treatment of recovered blood, the device comprising:
- a first fluid inlet configured for drawing a first portion of the recovered blood, the first portion received from a body cavity of a subject;
- a reservoir fluidly coupled to the first fluid inlet, the reservoir fluidly sealed relative to an external ambient environment and configured to maintain a negative internal pressure relative to the external ambient environment;
- an inline pump fluidly coupled to an outlet of the reservoir, the inline pump configured to regulate a flow rate of at least the first portion of the recovered blood, received from the first fluid inlet or the reservoir, through an outlet of the pump;
- an extracorporeal blood conditioner connected to the outlet of the pump, the conditioner configured to condition the recovered blood via at least one of:
- a temperature regulator configured to selectively control a temperature of the recovered blood;
- or
- an oxygenator configured to reoxygenate hemoglobin (Hb) included in the recovered blood, received from at least the reservoir, for at least intravenous delivery back to the subject via at least a first fluid outlet;
- a blood state sensor, configured to measure an indication of blood lactate concentration of at least the first portion of the recovered blood received via at least the first fluid inlet;
- and
- processing circuitry configured to monitor the measured indication of blood lactate concentration over time and to control operation of the device between:
- an assist mode, wherein the temperature regulator is configured to regulate the blood at a first temperature and configured to deliver reoxygenated blood back intravenously to the subject via the first fluid outlet after reoxygenation via the oxygenator;
- and
- a controlled preservation mode, configured to temporarily slow biological function of the subject to help preserve organ tissue, wherein the temperature regulator cools the recovered blood toward a second temperature lower than the first temperature before at least intraarterial delivery of the cooled blood back to the subject;
- wherein the controlling of the operation of the device between the assist mode and the controlled preservation mode is determined at least in part based on the monitored blood lactate concentration.
11 more elements
A system for performing extracorporeal blood treatment of recovered blood, the system comprising:
- a portable enclosure including:
- a first fluid inlet configured for drawing a first portion of the recovered blood, the first portion received from a body cavity of a subject;
- a reservoir fluidly coupled to the first fluid inlet, the reservoir fluidly sealed relative to an external ambient environment and configured to maintain a negative internal pressure relative to the external ambient environment;
- an inline pump fluidly coupled to an outlet of the reservoir, the inline pump configured to regulate a flow rate of at least the first portion of the recovered blood, received from the first fluid inlet or the reservoir, through an outlet of the pump;
- a blood state sensor, configured to measure an indication of blood state including blood lactate concentration, of at least the first portion of the recovered blood received via at least the first fluid inlet;
- an extracorporeal blood conditioner connected to the outlet of the pump, the conditioner configured to condition the recovered blood via at least one of:
- a temperature regulator configured to selectively control a temperature of the recovered blood;
- or
- an oxygenator configured to reoxygenate hemoglobin (Hb) included in the recovered blood, received from at least the reservoir, for at least intravenous delivery back to the subject via at least a first fluid outlet configured for delivering blood at least intravenously back to the subject;
- and
- a battery configured to power the inline pump and the blood conditioner;
- processing circuitry configured to monitor the measured indication of blood lactate concentration over time and to control operation of the system between:
- an assist mode, wherein the temperature regulator is configured to regulate the blood at a first temperature and configured to deliver reoxygenated blood back intravenously to the subject via the first fluid outlet after reoxygenation via the oxygenator;
- and
- a controlled preservation mode, configured to temporarily slow biological function of the subject to help preserve organ tissue, wherein the temperature regulator cools the recovered blood toward a second temperature lower than the first temperature before at least intraarterial delivery of the cooled blood back to the subject:
- wherein the controlling of the operation of the system between the assist mode and the controlled preservation mode is determined at least in part based on the monitored blood lactate concentration;
- and
- wherein the system is configured to output conditioned blood from the reservoir via the first fluid outlet at a greater rate than 200 milliliters per minute (mL/min).
15 more elements
Dependencies are inferred from the claim text.