Removal of microbubbles through drip chamber nucleation sites

A drip chamber for separating air from blood in a blood line, the drip chamber comprising:

• a hollow body having a top and a bottom;
• an inlet in fluid communication with the hollow body;
• and
• an outlet in fluid communication with the hollow body at the bottom of the hollow body,
• wherein the hollow body is defined by a sidewall that defines an interior space, the inlet is above at least a portion of the sidewall that defines the interior space, the sidewall comprises a material and has an inner surface, the inner surface has been treated by a treatment to form microfeatures in or on the inner surface, a population of the microfeatures at the inner surface is greater than a population of microfeatures at an inner surface of the same material but that has not been treated with said treatment, and the microfeatures provide an improved nucleation efficiency and nucleation sites for nucleation and amalgamation of microbubbles in a liquid that contacts the inner surface.