Hemostatic compositions and methods of making thereof
AssigneeGuangzhou Bioseal Co., Ltd.
InventorsShuang Chen, Yufu Li, Dengmin Feng, Xiang Wan
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Abstract
The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition.
Claims6
A method of forming a powdered hemostatic composition, comprising the steps of:
- a) forming a suspension of a mixture comprising particles of fibrinogen, thrombin, a calcium salt, a buffering agent, and oxidized regenerated cellulose (ORC) fibers in a non-aqueous low boiling solvent;
- b) spraying the suspension through a nozzle onto a substrate,
- c) allowing the non-aqueous solvent to evaporate;
- d) separating the composition from the substrate and sieving the composition;
- and thus forming the powdered hemostatic composition comprising an agglomerate of said (i) ORC fibers, (ii) fibrinogen, (iii) thrombin;
- (iv) calcium salt, and (v) buffering agent, said components (i)-(v) being at least partially integrated, wherein the weight ratio of said fibrinogen, thrombin and calcium salt to the ORC fibers ranges from about 1:1 to about 10:1, and wherein said ORC fibers are not per se neutralized by said buffering agent until said buffering agent is dissolved.
Dependencies are inferred from the claim text.