Method for treating active bleeding by sequentially applying a biocompatible hemostatic composition and a sealant composition
OwnerXin Ji, Xueshen Shi +1inventors
InventorsXin Ji, Xueshen Shi, Xiaoguang Zhang
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Abstract
The present specification describes a biocompatible hemostatic composition and a biocompatible tissue sealant, which when used in combination provides a safe and effective method of achieving hemostasis. The biocompatible composition and sealant may be applied either on a surface of the patient's body, or inside the body cavity. The combination may be used to control bleeding from external wounds and internal injuries, as well as to minimize bleeding during surgical procedures.
Claims14
A method of using a biocompatible carboxymethyl starch in combination with a biocompatible polyethylene glycol (PEG) blend to treat a bleeding wound within or on a mammal, comprising:
- applying a first amount of said biocompatible carboxymethyl starch to said bleeding wound;
- and,
- applying a second amount of said biocompatible polyethylene glycol (PEG) blend to the bleeding wound, wherein the biocompatible polyethylene glycol (PEG) blend comprises at least one of PEG succinimidyl glutarate blended with PEG thiol, PEG succinimidyl glutarate blended with PEG amine, PEG maleimide blended with PEG thiol, or PEG maleimide blended with PEG amine, wherein the first amount plus the second amount equals a total amount, wherein the first amount is approximately 75% of the total amount, wherein the second amount is approximately 25% of the total amount and wherein said first amount and said second amount in combination are sufficient to cause at least one of:
- hemostasis in said bleeding wound, wound sealing in said wound, reducing exudation of said bleeding wound, promoting tissue healing of said wound, protecting a surface of said wound, and avoiding infection of said wound.
Dependencies are inferred from the claim text.