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US 11,998,634 B2Granted
Micro- or nano emulsions including anticancer drugs
AssigneeCapnopharm GmbH
InventorRanjita Sahoo
Life of this patent
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Abstract
The invention relates to new emulsion formulations comprising polyethylene glycol (15)-hydroxystearate, polyglyceryl-3 oleate and one, two, three or more anti-cancer drugs as well as such emulsion formulations for use in the treatment of cancer and a method for producing such emulsion formulations. Preferably, the emulsion formulation can further comprise one or more immunomodulatory drugs or adjuvant.
Claims20
An emulsion formulation comprising:
- (a) 1 to 15 wt. % of polyethylene glycol (15)-hydroxystearate,
- (b) 0.3 to 10 wt. % of polyglyceryl-3 oleate,
- (c) at least one anti-cancer drug selected from oxaliplatin, cisplatin, doxorubicin, or paclitaxel,
- (d) optionally, polysorbate, and
- (e) water,
- wherein the emulsion is an oil-in-water micro- or nanoemulsion and all percentages by weight are based on a total weight of the emulsion formulation.
3 more elements
A method for treating cancer in a patient suffering from cancer comprising intraperitoneally administering to the patient an emulsion formulation comprising:
- (a) 1 to 15 wt. % of polyethylene glycol (15)-hydroxystearate,
- (b) 0.3 to 10 wt. % of polyglyceryl-3 oleate,
- (c) at least one anti-cancer drugs selected from oxaliplatin, cisplatin, doxorubicin, or paclitaxel,
- (d) optionally, polysorbate, and
- (e) water,
- wherein the emulsion is an oil-in-water micro- or nanoemulsion, the average particle size of the oil-in-water emulsion is from 10 to 1000 nm, and all percentages by weight are based on a total weight of the emulsion formulation.
3 more elements
Dependencies are inferred from the claim text.