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US 11,998,616 B2Granted
Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
AssigneeCalifornia Institute of Technology
InventorsMark E. Davis, Emily A. Wyent
Life of this patent
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Abstract
The present application discloses nanoparticles carrying therapeutic agents, including chemotherapeutic agents, and targeting ligands suitable for delivering these therapeutic agents through the blood brain barrier and methods of using these patients on those patients in need of such treatment.
Claims9
A method for slowing growth of a brain tumor by 82%-94%, the method comprising systemically administering, to a subject having the brain tumor, a nanoparticle comprising:
- (a) a nanoparticle core comprising a mucic acid-containing polymer;
- (b) transferrin joined to the nanoparticle core by a nitrophenyl boronic ester linkage to vicinal diols of the mucic acid-containing polymer;
- (c) trastuzumab;
- and
- (d) camptothecin.
2 more elements
Dependencies are inferred from the claim text.