Back to results
US 11,998,614 B2Granted
Compositions and methods for inducing scarring by peri-tumoral cells
AssigneeDuke University
InventorsTarun Saxena, Ravi Bellamkonda, Nassir Mokarram-Dorri
Life of this patent
Estimating the term…
Abstract
Compositions are provided, the compositions comprising: (1) a nanoparticle; (2) optionally, a linker and/or masking agent; and (3) a ligand configured to activate peri-tumoral cells to induce scarring by the peri-tumoral cells. In some aspects, administration of the compositions to a subject may generate an environment capable of walling-off and containing invasive tumors.
Claims10
A composition comprising a conjugate, the conjugate comprising:
- (1) a gold nanoparticle;
- (2) optionally, a linker or a masking agent;
- and (3) a ligand,
- wherein the ligand comprises an isolated water-soluble mixture of zymosan polypeptides obtained by extracting zymosan with an extraction buffer comprising CHAPS detergent and applying the CHAPS detergent extract to a 10 kDa centrifugal spin column, and
- wherein the conjugate has a diameter of about 50 nm to about 200 nm.
2 more elements
A composition comprising:
- (1) a nanoparticle;
- and (2) a ligand, wherein the ligand comprises an isolated water-soluble mixture of zymosan polypeptides obtained by extracting zymosan with an extraction buffer comprising CHAPS detergent and applying the CHAPS detergent extract to a 10 kDa centrifugal spin column, wherein the nanoparticle forms a conjugate with the ligand or encapsulates the ligand, and wherein the conjugate or the nanoparticle encapsulating the ligand has a diameter of about 5 nm to about 200 nm and is capable of crossing the blood brain barrier.
Dependencies are inferred from the claim text.