Loading patent…
AssigneeThe General Hospital Corporation
InventorsPatricia K. Donahoe, David Pepin
Estimating the term…
One aspect of the invention provides a method of contraception by administering to a female subject a composition comprising Mullerian inhibiting substance (MIS). The MIS can be produced endogenously in the subject by a vector, where the vector comprises a polynucletide encoding a recombinant MIS protein. In some embodiments, the contraception is permanent and only requires administration of the composition once. Another aspect of the invention relates to a method of preserving an ovarian reserve, the method comprising administering to a female subject a composition comprising MIS or an inducible vector that comprises a polynucleotide encoding a recombinant MIS protein.
A method of permanent contraception in a female cat comprising administering to the female cat an effective amount of a composition comprising a viral vector comprising one or more regulatory elements operatively linked to a nucleic acid encoding a wild-type Mullerian Inhibiting Substance (MIS) protein for permanent contraception in the female cat, wherein the effective amount of the composition administered to the female cat increases the concentration of MIS protein in the blood of the female cat to a MIS serum concentration of about 0.3 μg/ml to about 5 μg/ml.
A method of arresting folliculogenesis in a female cat comprising administering to the female cat an effective amount of a composition comprising a viral vector comprising one or more regulatory elements operatively linked to a nucleic acid encoding a wild-type Mullerian Inhibiting Substance (MIS) protein, wherein folliculogenesis is arrested in the female cat, wherein the effective amount of the composition administered to the female cat increases the concentration of MIS protein in the blood of the female cat to a MIS serum concentration of about 0.3 μg/ml to about 5 μg/ml.
A method of permanent contraception in a female cat comprising administering to the female cat an effective amount of a composition comprising a viral vector comprising one or more regulatory elements operatively linked to a nucleic acid encoding a wild-type Mullerian Inhibiting Substance (MIS) protein for permanent contraception in the female cat, wherein the effective amount of the composition administered to the female cat increases the concentration of MIS protein in the blood of the female cat to a MIS serum concentration of about 0.3 μg/ml to about 1.5 μg/ml.
Dependencies are inferred from the claim text.