Compositions comprising antimicrobial peptides
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsKenneth Urish, Jonathan Brendan Mandell
Life of this patent
Estimating the term…
Abstract
A method of treating or preventing a microbial infection in a patient is provided, along with a wound irrigation system and a composition in the form of an irrigation liquid for reducing microbial load or preventing microbial infection in a wound.
Claims66
A method of treating or preventing an infection in a subject in need thereof, comprising administering a pharmaceutical composition to an open wound, an implant, a medical device, a prosthetic, or any part thereof of the subject, wherein the infection comprises a biofilm, thereby treating or preventing the infection, wherein the pharmaceutical composition comprises:
- a. a cationic antimicrobial peptide or pharmaceutically acceptable salt thereof, wherein the cationic antimicrobial peptide is SEQ ID NO:
- 10;
- and
- b. a pharmaceutically acceptable aqueous carrier;
- wherein the pharmaceutical composition is in the form of a liquid;
- wherein the cationic antimicrobial peptide is present at a concentration of about 3 mg/mL to about 30 mg/mL, and wherein the pharmaceutical composition has a total osmolarity from about 50 mOsm/L to about 350 mOsm/L.
A method of treating or preventing an infection in a subject in need thereof, comprising irrigating an open wound, an implant, a medical device, a prosthetic, or any part thereof of the subject using a pharmaceutical composition, wherein the infection comprises a biofilm, thereby treating or preventing the infection, wherein the pharmaceutical composition comprises:
- a. a cationic antimicrobial peptide or pharmaceutically acceptable salt thereof, wherein the cationic antimicrobial peptide is SEQ ID NO:
- 10, and wherein the cationic antimicrobial peptide is present at a concentration of about 3 mg/mL to about 30 mg/mL;
- and
- b. a pharmaceutically acceptable aqueous carrier;
- wherein the pharmaceutical composition is in the form of a liquid;
- and wherein the irrigating is performed at least once a day.
A method of treating or preventing an infection in a subject in need thereof, comprising irrigating an open wound, an implant, a medical device, a prosthetic, or any part thereof of the subject using a pharmaceutical composition, wherein the infection comprises a biofilm, thereby treating or preventing the infection, wherein the pharmaceutical composition comprises:
- a. a cationic antimicrobial peptide or pharmaceutically acceptable salt thereof, wherein the cationic antimicrobial peptide is SEQ ID NO:
- 10, and wherein the cationic antimicrobial peptide is present at a concentration of about 3 mg/mL to about 30 mg/mL;
- and
- b. a pharmaceutically acceptable aqueous carrier;
- wherein the pharmaceutical composition is in the form of a liquid;
- and wherein the irrigating using the pharmaceutical composition is performed for a period ranging from about 0.1 min to about 30 min.
A method of treating or preventing an infection in a subject in need thereof, comprising administering a pharmaceutical composition to an open wound, an implant, a medical device, a prosthetic, or any part thereof of the subject, wherein the infection comprises a biofilm, thereby treating or preventing the infection, wherein the pharmaceutical composition comprises:
- a. a cationic antimicrobial peptide or pharmaceutically acceptable salt thereof, wherein the cationic antimicrobial peptide is SEQ ID NO:
- 10, and wherein the cationic antimicrobial peptide is present at a concentration of about 3 mg/mL to about 30 mg/mL;
- and
- b. a pharmaceutically acceptable aqueous carrier;
- wherein the pharmaceutical composition is in the form of a liquid, and wherein the pharmaceutical composition is physiologically isotonic or physiologically hypotonic.
A method of treating or preventing an infection in a subject in need thereof, comprising administering a pharmaceutical composition to an open wound, an implant, a medical device, a prosthetic, or any part thereof of the subject, wherein the infection comprises a biofilm, thereby treating or preventing the infection, wherein the pharmaceutical composition comprises:
- a. a cationic antimicrobial peptide or pharmaceutically acceptable salt thereof, wherein the cationic antimicrobial peptide is SEQ ID NO:
- 10, and wherein the cationic antimicrobial peptide is present at a concentration of about 3 mg/mL to about 30 mg/mL;
- and
- b. a pharmaceutically acceptable aqueous carrier;
- wherein the pharmaceutical composition is in the form of a liquid;
- and wherein the pharmaceutical composition comprises a total ionic strength from about 0.02 M to about 0.2 M.
A method of treating or preventing an infection in a subject in need thereof, comprising administering a pharmaceutical composition to an open wound, an implant, a medical device, a prosthetic, or any part thereof of the subject, wherein the infection comprises a biofilm, thereby treating or preventing the infection, wherein the pharmaceutical composition comprises:
- a. a cationic antimicrobial peptide or pharmaceutically acceptable salt thereof, wherein the cationic antimicrobial peptide is SEQ ID NO:
- 10, and wherein the cationic antimicrobial peptide is present at a concentration of about 10 mg/mL;
- and
- b. a pharmaceutically acceptable aqueous carrier;
- wherein the pharmaceutical composition is in the form of a liquid.
A method of treating or preventing an infection in a subject in need thereof, comprising injecting a pharmaceutical composition to an open wound, an implant, a medical device, a prosthetic, or any part thereof of the subject, thereby treating or preventing the infection, wherein the pharmaceutical composition comprises:
- a. a cationic antimicrobial peptide or pharmaceutically acceptable salt thereof, wherein the cationic antimicrobial peptide is SEQ ID NO:
- 10, and wherein the cationic antimicrobial peptide is present at a concentration of about 3 mg/mL to about 30 mg/mL;
- and
- b. a pharmaceutically acceptable aqueous carrier;
- wherein the pharmaceutical composition is in the form of a liquid.
Dependencies are inferred from the claim text.