Methods and compositions for increasing the dose of a chemotherapeutic agent
AssigneeStealth BioTherapeutics Inc.
InventorD. Travis Wilson
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Abstract
The disclosure relates to methods for treating a subject suffering from hyperalgesia caused by drug-induced neuropathy by administering to the subject an effective amount of an aromatic-cationic peptide. The disclosure also relates to methods for protecting a subject from hyperalgesia caused by drug-induced neuropathy by administering an effective amount of an aromatic-cationic peptide to a subject at risk for developing the condition.
Claims9
A method for increasing the dose of a chemotherapeutic agent in a subject in need thereof, comprising administering to the subject an effective amount of a peptide having the formula Phe-D-Arg-Phe-Lys-NH2, or a pharmaceutically acceptable salt thereof, wherein the peptide treats or prevents one or more dose-limiting neuropathic conditions induced by the chemotherapeutic agent, thereby permitting an increase in the dose of the chemotherapeutic agent.
Dependencies are inferred from the claim text.