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US 11,998,580 B2Granted
Group B adenovirus-containing formulation
AssigneeAkamis Bio Limited
InventorsSimon Alvis, Magdalena Kieltyka
Life of this patent
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Abstract
The present disclosure provides a liquid formulation suitable for a group B adenovirus, comprising: a) a group B adenovirus, such as replication competent group B adenovirus, b) 15 to 25% v/v glycerol, for example 16, 17, 18, 19, 20, 21% v/v glycerol; and c) 0.1 to 1.5% v/v ethanol, for example 0.2-1%, such as 1% v/v ethanol; and d) a buffer, and e) optionally an amino acid, wherein the pH of the formulation is in the range 8.0 to 9.6, and use of the same in treatment, particular in the treatment of cancer.
Claims17
A liquid formulation suitable for a group B adenovirus, comprising:
- a) a group B adenovirus,
- b) 15 to 25% v/v glycerol;
- c) 0.1 to 1.5% v/v ethanol;
- d) 0.01-0.3 mM methionine;
- and
- e) a buffer,
- wherein:
- the pH of the formulation is in the range 8.0 to 9.6, and
- the formulation does not comprise a sugar.
6 more elements
Dependencies are inferred from the claim text.