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AssigneeSeed Health, Inc.
InventorsSheri Simmons, Tye Jensen, Raja Dhir, Joseph E. Kovarik
Estimating the term…
Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria, postbiotics, metabolites and other microbe components to foster the growth and maintenance of a healthy skin microbiome. One embodiment includes a topical application of Lactobacillus crispatus to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, postbiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne, through the production of tryptophan metabolites that act as AHR agonists.
A method of modulating an individual's skin microbiome, comprising:
A method of modulating an individual's skin microbiome, comprising, administering to a region of an individual's skin who has a skin condition a therapeutically effective amount of a bacterial formulation comprising Lactobacillus crispatus, and at least two bacteria selected from the group consisting of Lactobacillus reuteri, Lactobacillus johnsonii, Cutibacterium acnes, Janthinobacterium and Nitrosomonas eutropha, said bacterial formulation comprising a lotion, ointment or gel adapted to be rubbed onto a region of the individual's skin, and abiotic augmentations comprising fatty acids, wherein the at least two bacteria comprise heat-killed bacteria and wherein the skin condition is selected from the group consisting of eczema, atopic dermatitis, acne, allergic inflammation, impetigo, ultra-violet-induced skin damage, and skin hypersensitivity.
A method of modulating an individual's skin microbiome, comprising, topically administering to a region of an individual's skin a therapeutically effective amount of a bacterial formulation comprising heat-killed Lactobacillus crispatus bacteria, and at least one of Lactobacillus reuteri, Lactobacillus johnsonii, Lactobacillus crispatus, Cutibacterium acnes, Bifidobacterium lognum and Nitrosomonas eutropha, said bacterial formulation comprising a lotion, ointment or gel adapted to be rubbed onto a region of the individual's skin, and wherein the bacterial formulation further comprises Janthinobacterium.
Dependencies are inferred from the claim text.