Stable cardioplegic solution for cardiac surgery

A cardioplegic solution comprising potassium (K+), magnesium (Mg2+), sodium (Na+), chloride (Cl−), gluconate, acetate, sulfate (SO42−), tris(hydroxymethyl)aminomethane (THAM) and mannitol dissolved in water, wherein the potassium (K+) concentration is about 27 to about 33 mEq/L, the magnesium (Mg2+) concentration is about 16 to about 20 mEq/L, the sodium (Na+) concentration is about 120 to about 146 mEq/L, the chloride (Cl−) concentration is about 106 to about 130 mEq/L, the gluconate concentration is about 20 to about 24 mmol/L, the acetate concentration is about 22 to about 28 mmol/L, the sulfate (SO42−) concentration is about 6 to about 9 mmol/L, the THAM concentration is between about 5 to about 30 mmol/L, mannitol concentration is about 2 to about 5 g/L and the cardioplegic solution is capable of maintaining a pH of about 8.2 to about 8.6 for 365 days wherein the term “about” as a modifier to a quantity is intended to mean+ or −5% inclusive of the quantity being modified.