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US 11,998,563 B2Granted
Polymeric treatment compositions
AssigneeMicroVention, Inc.
InventorsGregory M. Cruise, Michael J. Constant, Joshua Garretson
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Abstract
Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
Claims11
A composition comprising:
- a biocompatible polymer comprising:
- a first monomer wherein the first monomer is t-butyl acrylate;
- a second monomer wherein the second monomer is an alkyl acrylate comprising a hydroxyl group;
- and
- a third monomer wherein the third monomer is hydroxyethyl methacrylate;
- a pH-sensitive component, wherein the pH-sensitive component is selected from aminopropyl methacrylamide, aminoethyl methacrylamide, N-(3-methylpyridine)acrylamide, N-(2-(4-aminophenyl)ethyl)acrylamide, N-(4-aminobenzyl)acrylamide, N-(2-(4-imidazolyl)ethyl)acrylamide, derivatives thereof, and combinations thereof;
- an aqueous solution with a non-physiological pH;
- and
- a visualization agent;
- wherein the biocompatible polymer is soluble in the aqueous solution and insoluble at a physiological pH at a treatment site.
7 more elements
Dependencies are inferred from the claim text.