Synthetic composition for treating antibiotic associated complications
AssigneeGlycom A/S
InventorsBruce McConnell, Louise Kristine Vigsnæs, David Paul Kronlage
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Abstract
The invention relates to a synthetic composition comprising human milk oligosaccharides for use in at least partially restoring the commensal gastrointestinal microbiota and preventing or mitigating antibiotic associated diarrhoea.
Claims10
A method of treating a disorder associated with antibiotic therapy comprising administering daily to a human in need thereof at least 2 g of a synthetic composition consisting essentially of one or more human milk oligosaccharides (HMOs) selected from the group consisting of fucosylated HMOs and core HMOs, and optionally, a probiotic,
- wherein the disorder associated with antibiotic therapy is selected from the group consisting of diarrhoea, dysbiosis of the lower gastro-intestinal tract, and primary or recurrent Clostridium difficile infection, and wherein the human is undergoing or had previously undergone antibiotic therapy.
The method according to 1, wherein the one or more HMOs consists essentially of a mixture of one or more fucosylated HMOs and one or more core HMOs.
Dependencies are inferred from the claim text.