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US 11,998,555 B2Granted
Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same
AssigneescPharmaceuticals Inc.
InventorsAlfredo Grossi, Britt Kostraba, Olatokumbo O. Luca Ogunleye, Shannon Terry, Franciscus Koppenhagen
Life of this patent
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Abstract
Disclosed herein, in part, are liquid pharmaceutical formulations comprising furosemide or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable excipients, and a pharmaceutically acceptable buffer. Methods of treating congestion, edema, fluid overload, or hypertension in a patient in need thereof are also provided.
Claims20
A liquid pharmaceutical formulation comprising:
- (i) furosemide, or a pharmaceutically acceptable salt thereof;
- (ii) benzyl alcohol, wherein the amount of benzyl alcohol in the liquid pharmaceutical formulation is from about 0.1% (w/w) to about 10% (w/w);
- and
- (iii) a pharmaceutically acceptable buffer comprising tromethamine or a pharmaceutically acceptable salt thereof, wherein the concentration of tromethamine is from about 25 mM to about 100 mM,
- wherein the concentration of furosemide in the liquid pharmaceutical formulation is greater than about 40 mg/mL and the pH of the liquid pharmaceutical formulation is from about 6.5 to about 8.5.
2 more elements
A liquid pharmaceutical formulation, comprising:
- (i) furosemide, or a pharmaceutically acceptable salt thereof;
- (ii) from about 0.1% (w/w) to about 10% (w/w) benzyl alcohol;
- and
- (iii) from about 25 mM to about 100 mM tromethamine or a pharmaceutically acceptable salt thereof,
- wherein the concentration of furosemide in the liquid pharmaceutical formulation is from about 40 mg/mL to about 250 mg/mL.
2 more elements
A unit liquid pharmaceutical formulation comprising:
- (i) from about 10 mg to about 200 mg furosemide, or a pharmaceutically acceptable salt thereof;
- (ii) from about 0.1% (w/w) to about 10% (w/w) benzyl alcohol;
- and
- (iii) from about 25 mM to about 100 mM tromethamine or a pharmaceutically acceptable salt thereof,
- wherein the concentration of furosemide in the unit liquid pharmaceutical formulation is from about 40 mg/mL to about 200 mg/mL and the pH of the unit liquid pharmaceutical formulation is from about 6.5 to about 8.5.
2 more elements
Dependencies are inferred from the claim text.