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US 11,998,546 B2Granted
Pharmaceutical combinations comprising a histone deacetylase inhibitor and epothilone and methods of use thereof
AssigneeAcetylon Pharmaceuticals, Inc.
InventorsPengyu Huang, Steven Quayle
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Abstract
The present disclosure relates to a pharmaceutical combination comprising (a) a histone deacetylase 6 inhibitor and (b) an epothilone, including combined preparations and pharmaceutical compositions thereof; uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.
Claims7
A method for treating ovarian cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of
- (a) a histone deacetylase 6 (HDAC6) inhibitor, wherein the HDAC6 inhibitor is:
- or a pharmaceutically acceptable salt thereof;
- or
- or a pharmaceutically acceptable salt thereof;
- and
- (b) an epothilone selected from the group consisting of epothilone A, epothilone B, epothilone C, epothilone D, epothilone E, and epothilone F, or pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.