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US 11,998,544 B2Granted
Methods of using splicing modulators
AssigneeEisai R&D Management Co., Ltd.
InventorsErmira Pazolli, Silvia Buonamici, James Palacino, Michael Seiler, Ping Zhu, Evan Barry, Lihua Yu
Life of this patent
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Abstract
This disclosure relates to methods for the treatment of neoplastic disorders by administering Compound 1, or a pharmaceutically acceptably salt thereof, on its own and/or as part of a conjugate or composition, and inducing production of at least one neoantigen.
Claims12
A method of treating a subject having or suspected of having a neoplastic disorder, comprising administering to the subject a therapeutically effective amount of Compound 1
- or a pharmaceutically acceptable salt thereof, and at least one additional therapy comprising a CTLA4 inhibitor, and wherein the neoplastic disorder is selected from myelodysplastic syndrome, chronic lymphocytic leukemia, acute lymphoblastic leukemia, chronic myelomonocytic leukemia, acute myeloid leukemia, and colon cancer.
Dependencies are inferred from the claim text.