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AssigneesIndustry-Academic Cooperation Foundation, Yonsei University, National Cancer Center
InventorsSeok-Gu Kang, Soo Youl Kim
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The present disclosure relates to a pharmaceutical composition for treating brain cancer containing an aldehyde inhibitor and an anticancer drug. Since there are many types of brain cancer and the boundary between brain cells and tumor cells in brain cancer is not clear, brain cancer is particularly difficult to treat. The pharmaceutical composition of the present disclosure may further contain a biguanide-based compound as needed, wherein the compound is preferably phenformin. The pharmaceutical composition of the present disclosure is very effective for the treatment and improvement of prognosis of brain cancer, and has remarkable effects of killing cancer cells and inhibiting cancer stem cell characteristics, compared to when each of the active ingredients is administered alone. Thus, it is expected that the pharmaceutical composition of the present disclosure will be widely used in the field of brain cancer treatment.
A method for preventing or treating brain cancer in a patient or for suppressing brain cancer metastasis in a patient, the method comprising administering to the patient a pharmaceutical composition comprising gossypol, phenformin and temozolomide as active ingredients.
A method for preventing or treating brain cancer or for suppressing brain cancer metastasis in a patient, the method comprising administering to the patient gossypol, phenformin and temozolomide as active ingredients.
Dependencies are inferred from the claim text.