Substituted indole dimer compounds

A compound of Formula (I)

• or N-oxide or a salt thereof, wherein:
• L is —(CH2)q— or -L1-NRxC(O)—(CH2)t—C(O)NRx-L2-;
• L1 and L2 are independently —(CH2)1-3—;
• q is an integer in the range of 10 to 30;
• t is an integer in the range of 2 to 24;
• G1 and G2 are independently:
• (iv) a 9-membered heterocyclic ring selected from:
• or
• (v) 10-membered heterocyclic ring selected from:
• R1a and R1b are independently H, Cl, —CN, C1-4 alkyl, C1-3 fluoroalkyl, C1-3 hydroxyalkyl, hydroxy-fluoroalkyl, C3-6 cycloalkyl, —CH2(C3-6 cycloalkyl), —C(O)O(C1-3 alkyl), or tetrahydropyranyl;
• each R2 is independently halo, —CN, —OH, —NO2, C1-4 alkyl, C1-2 fluoroalkyl, C1-2 cyanoalkyl, C1-3 hydroxyalkyl, C1-3 aminoalkyl, —O(CH2)1-2OH, —(CH2)0-4O(C1-4 alkyl), C1-3 fluoroalkoxy, —(CH2)1-4O(C1-3 alkyl), —O(CH2)1-2OC(O)(C1-3 alkyl), —O(CH2)1-2NRxRx, —C(O)O(C1-3 alkyl), —(CH2)0-2C(O)NRyRy, —C(O)NR4C1-5 hydroxyalkyl), —C(O)NRx(C2-6 alkoxyalkyl), —C(O)NRx(C3-6 cycloalkyl), —NRyRy, —NRy(C1-3 fluoroalkyl), —NRy(C1-4 hydroxyalkyl), —NRxH2(phenyl), —NRxS(O)2(C3-6 cycloalkyl), —NRx(O)(C1-3 alkyl), —NRxH2(C3-6 cycloalkyl), —(CH2)0-2S(O)2(C1-3 alkyl), —(CH2)0-2(C3-6 cycloalkyl), —(CH2)0-2(phenyl), morpholinyl, dioxothiomorpholinyl, dimethyl pyrazolyl, methylpiperidinyl, methylpiperazinyl, amino-oxadiazolyl, imidazolyl, triazolyl, or —C(O)(thiazolyl);
• R2a is C1-6 alkyl, C1-3 fluoroalkyl, C1-6 hydroxyalkyl, C1-3 aminoalkyl, —(CH2)0-4O(C1-3 alkyl), C3-6 cycloalkyl, —(CH2)1-3C(O)NRxRx, —CH2(C3-6 cycloalkyl), —CH2(phenyl), tetrahydrofuranyl, tetrahydropyranyl, or phenyl;
• each R2b is independently H, halo, —CN, —NRxRx, C1-6 alkyl, C1-3 fluoroalkyl, C1-3 hydroxyalkyl, C1-3 fluoroalkoxy, —(CH2)0-2O(C1-3 alkyl), —(CH2)0-3C(O)NRxRx, —(CH2)1-3(C3-6 cycloalkyl), —C(O)O(C1-3 alkyl), —C(O)NR4C1-3 alkyl), —CRx═CRxRx, or —CRx═CH(C3-6 cycloalkyl);
• R2c is R2a or R2b;
• R2d is R2a or R2b;
• provided that one of R2c and R2d is R2a, and the other of R2c and R2 is R2b;
• each R4 is independently F, —OH, C1-2 alkyl, or —OCH3;
• or two R4 attached to the same carbon atom form ═O;
• or wherein when m or n is at least 2, two R4, each attached to a different carbon atom adjacent to the nitrogen atom in a piperidinyl ring, can form a —CH2CH2— bridge;
• each R5 is independently F, Cl, —CN, C1-3 alkyl, C1-2 fluoroalkyl, or —OCH3;
• each Rx is independently H or —CH3;
• each Ry is independently H or C1-6 alkyl;
• m is zero, 1, 2, 3, or 4;
• n is zero, 1, 2, 3, or 4;
• each p is independently zero, 1, 2, 3, or 4;
• x is zero, 1, or 2;
• and
• y is zero, 1, or 2.