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US 11,998,536 B2Granted
Decreasing expression level of proteasome subunit genes by treating a human subject with a nitroxide
OwnerLouis Habashinventor
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Abstract
Some embodiments disclosed herein include a method for decreasing gene expression of a gene. The methods can include identifying a human subject over the age of 35 and having an increase expression level of a gene associated with proteasome activity; and administering to the human subject an effective amount of a nitroxide antioxidant, whereby expression level of the gene is decreased.
Claims10
A method for decreasing the expression level of Psma6 in a human subject, the method comprising:
- identifying the human subject both having an increased expression level of Psma6 and having a disease associated with the increased expression level Psma6;
- and
- administering an effective amount of a nitroxide antioxidant to the human subject,
- the nitroxide antioxidant selected from the group consisting of 2-ethyl-2,5,5-trimethyl-3-oxazolidine-1-oxyl (OXANO), 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), 4-amino-2,2,6,6-tetramethyl-1-piperidinyloxy (Tempamine), 3-Aminomethyl-PROXYL, 3-Cyano-PROXYL, 3-Carbamoyl-PROXYL, 3-Carboxy-PROXYL, and 4-Oxo-TEMPO,
- whereby the expression level of Psma6 is decreased,
- wherein the disease associated with the increased expression level of Psma6 is atherosclerosis, and
- wherein identifying the human subject having an increased expression level of Psma6 comprises measuring the expression level of Psma6 in the human subject.
4 more elements
Dependencies are inferred from the claim text.