Pharmaceutical compositions comprising LTV-17 and beta-lactamase inhibitors and their use as antibacterial agents
AssigneeFedora Pharmaceuticals Inc.
InventorsSameeh M. Salama, Samarendra N. Maiti, Renata Jankowska
Life of this patent
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Abstract
Pharmaceutical combinations of LTV-17 (I), a lactivicin derivative, and β-lactamase inhibitors are provided, wherein the combinations comprise antibacterial agents suitable for use in the treatment or prevention of bacterial infections.
Claims14
A synergistic pharmaceutical combination comprising compound LTV-17 (I) or a pharmaceutically acceptable salt thereof, solvate thereof, or solvate of the salt thereof:
- and one or more β-lactamase inhibitor or a pharmaceutically acceptable salt thereof or a biologically hydrolysable prodrug thereof.
A method of treating or preventing a bacterial infection in a subject, comprising administering a therapeutically effective amount of pharmaceutical combination comprising compound LTV-17 (I) or a pharmaceutically acceptable salt thereof, solvate thereof, or solvate of the salt thereof:
- and one or more β-lactamase inhibitor or a pharmaceutically acceptable salt thereof or a biologically hydrolysable prodrug thereof, to a subject having a bacterial infection, wherein the combination has a synergistic anti-bacterial effect.
Dependencies are inferred from the claim text.