Substituted 1,3,4-oxadiazole derivatives as anti-tubercular agents
AssigneeKing Faisal University
InventorsKatharigatta N. Venugopala, Pran Kishore Deb, Melendran Pillay, Rashmi Venugopala
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Abstract
Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are substituted 1,3,4-oxadiazole derivatives and their use as anti-tubercular agents are provided.
Claims16
A method of treating tuberculosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- R, R1, and R2 may be the same or different and are independently selected from the group consisting of hydrogen, halogen, nitro, and methyl.
A method of treating tuberculosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- R, R1, and R2 may be the same or different and are independently selected from the group consisting of hydrogen, chlorine, fluorine, bromine, nitro, and methyl.
A method of treating tuberculosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of:
- 2-(1-(5-Chloro-2-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)-5-(4-chlorophenyl)-1,3,4-oxadiazole (7a);
- 2-(1-(5-Chloro-2-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)-5-(4-fluorophenyl)-1,3,4-oxadiazole (7b);
- 2-(3-Bromo-4-methylphenyl)-5-(1-(5-chloro-2-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)-1,3,4-oxadiazole (7c);
- 2-(1-(5-Chloro-2-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4-oxadiazole (7d);
- 2-(4-Bromophenyl)-5-(1-(5-chloro-2-methoxyphenyl)-5-methyl-1Hpyrazol-4-yl)-1,3,4-oxadiazole (7e);
- 2-(4-Bromo-3-methylphenyl)-5-(1-(5-chloro-2-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)-1,3,4-oxadiazole (7f);
- 2-(1-(5-Chloro-2-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)-5-(3-fluorophenyl)-1,3,4-oxadiazole (7g);
- 2-(1-(5-Chloro-2-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)-5-(3,5-dichlorophenyl)-1,3,4-oxadiazole (7h);
- 2-(1-(5-Chloro-2-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)-5-(3,4-dichlorophenyl)-1,3,4-oxadiazole (7i);
- 2-(1-(5-Chloro-2-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)-5-(4-methyl-3-nitrophenyl)-1,3,4-oxadiazole (7j);
- and a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof.
Dependencies are inferred from the claim text.