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US 11,998,519 B2Granted
Compositions and methods for prevention and reduction of traumatic brain injury
OwnerRob D. Dickermaninventor
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Abstract
Compositions and methods are presented that, upon administration prior to trauma, are effective to prevent and/or reduce severity of sequelae of TBI upon trauma. Advantageously, the compositions presented herein can be orally administered, have an excellent safety profile, and will not require a prescription by physician or hospital admission.
Claims16
A method of prophylactic neuroprotection that prevents or reduces at least one sequelae of traumatic brain injury (TBI), comprising:
- orally administering to a subject about to engage in an activity selected from a contact sport, a motor sport, and a military engagement a composition that comprises a branched chain amino acids (BCAA) component and a vitamin component at least 10 minutes prior to participating in the activity;
- wherein the BCAA component comprises leucine, valine, and isoleucine, and wherein the leucine, the valine, and the isoleucine are present in the BCAA component at a weight ratio of X:1:1, with X being between 2-4;
- wherein the vitamin component comprises vitamin B7 and at least one vitamin selected from the group consisting of vitamin C, vitamin B3, vitamin B5, vitamin B6, vitamin B9, and vitamin B12;
- and
- wherein the sequelae of TBI are selected from cognitive dysfunction, behavioral dysfunction, motor neural dysfunction, vestibular dysfunction, cerebral inflammation, and hyperglycemia.
2 more elements
Dependencies are inferred from the claim text.