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US 11,998,515 B1Granted
Enhancement of curcumin plasma levels using eucalyptol co-administration
AssigneeKing Faisal University
InventorsMaged Elsayed Mohamed, Nancy Safwat Younis
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Abstract
Compositions and methods for co-administering curcumin and eucalyptol to a subject. Through the combined administration with eucalyptol, the plasma levels of curcumin will increase over the current baseline, thereby increasing the medicinal activity of the polyphenol and contributing to the reduction of an effective dose thereof, thereby also decreasing the incidence of side effects.
Claims6
A method of increasing curcumin plasma levels in a subject, the method comprising:
- orally administering a composition to a subject in need thereof, wherein the composition comprises:
- about 10 mg of curcumin per kg of body weight in a subject to which the composition is administered;
- about 5 mg to about 20 mg of eucalyptol per kg of body weight in the subject to which the composition is administered;
- and
- an orally acceptable carrier that is saline;
- wherein the curcumin and the eucalyptol are solubilized in carboxy methyl cellulose;
- and
- wherein the curcumin and the eucalyptol are co-administered to the subject, wherein the curcumin plasma levels in the subject increased by 6-9 times from baseline plasma levels of curcumin in a subject who is untreated with the composition following oral administration of the composition to the subject.
5 more elements
Dependencies are inferred from the claim text.