Two-part nitric oxide generating topical compositions

A method for regulating nitric oxide release from a topical composition, the method comprising:

• mixing an effective amount of a first composition including a S-nitrosothiol nitric oxide donor and a carrier that includes petroleum jelly with an effective amount of a second composition including zinc oxide to form a mixture, the effective amounts of the first composition to the second composition correspond to a weight ratio ranging from about 50:50 to about 20:80;
• and
• heating the mixture to a temperature ranging from about 20° C. to about 40° C.

A method for treating a skin ailment, the method comprising:

• mixing an effective amount of a first composition including a S-nitrosothiol nitric oxide donor and a carrier that includes petroleum jelly with an effective amount of a second composition including zinc oxide to form a mixture, the effective amounts of the first composition to the second composition correspond to a weight ratio ranging from about 50:50 to about 20:80;
• and
• applying the mixture to skin, whereby the mixture is heated to a temperature ranging from about 20° C. to about 40° C. and the zinc oxide reacts with the S-nitrosothiol nitric oxide donor to enhance a rate of release of nitric oxide.