Method and apparatus for subretinal administration of therapeutic agent

An apparatus, comprising:

• (a) a body;
• (b) a cannula extending distally from the body along a longitudinal axis, wherein the cannula is flexible, wherein the cannula has a non-circular cross-sectional profile, wherein the cannula includes an atraumatic distal end, wherein the atraumatic distal end is configured to provide separation between a choroid and a sclera of an eye of a patient during advancement of the cannula between the choroid and the sclera;
• and
• (c) a needle slidably disposed in the cannula, wherein the needle includes a sharp distal tip, wherein the needle is configured to translate relative to the cannula between a proximal position and a distal position, wherein the distal tip is configured to be positioned inside the cannula when the needle is in the proximal position, wherein the distal tip is configured to be positioned outside the cannula when the needle is in the distal position, wherein the needle is resiliently biased toward an angled state in which at least a portion of the needle is oriented at a predetermined angle relative to the longitudinal axis.

An apparatus, comprising:

• (a) a body;
• (b) a cannula extending distally from the body along a longitudinal axis, wherein the cannula is flexible, wherein the cannula includes an atraumatic distal end, wherein the atraumatic distal end is configured to provide separation between a choroid and a sclera of an eye of a patient during advancement of the cannula between the choroid and the sclera;
• and
• (c) a needle slidably disposed in the cannula, wherein the needle includes a sharp distal tip, wherein the needle is configured to translate relative to the cannula between a proximal position and a distal position, wherein the distal tip is configured to be positioned inside the cannula when the needle is in the proximal position, wherein the distal tip is configured to be positioned outside the cannula when the needle is in the distal position, wherein the needle is resiliently biased toward an angled state in which at least a portion of the needle is oriented at a predetermined angle relative to the longitudinal axis.