Biodegradable vascular grafts
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsRobert Andrew Allen, Chelsea Elizabeth Stowell, Yadong Wang
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Abstract
A method of fabricating a vascular graft that includes preparing a biodegradable polyester electrospun tubular core; applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core; and surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath.
Claims21
A method of fabricating a vascular graft, comprising:
- preparing a biodegradable polyester electrospun tubular core;
- applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core;
- and
- surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath, wherein the poly(lactide) copolymer adhesive composition has a biodegradation rate that is between the biodegradation rate of the polyester electrospun tubular core and the biodegradation rate of the polyester sheath.
A method of fabricating a vascular graft, comprising:
- preparing a biodegradable polyester electrospun tubular core;
- applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core;
- and
- surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath, wherein the poly(lactide) copolymer adhesive composition has an elastic modulus of about 100 kPa to about 10 MPa.
A method of fabricating a vascular graft, comprising:
- preparing a biodegradable polyester electrospun tubular core;
- applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core;
- and
- surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath, wherein the poly(lactide) copolymer adhesive composition has a strain recovery of at least 80% at 10% strain.
A method of fabricating a vascular graft, comprising:
- preparing a biodegradable polyester electrospun tubular core;
- applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core;
- and
- surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath, wherein the amount of poly(lactide) copolymer adhesive composition applied to the outer surface of the biodegradable polyester electrospun tubular core is 50-1000 μl per cm2.
Dependencies are inferred from the claim text.