Membrane for continuous analyte sensors

A device for measurement of a concentration of an analyte the device comprising:

• a sensor configured to generate a signal indicative of the concentration of the analyte;
• and
• a sensing membrane located over the sensor, the sensing membrane comprising:
• an enzyme domain comprising:
• an enzyme,
• an enzyme stabilizing reagent comprising from 10 wt. % to 50 wt. % of the enzyme wt. % in the enzyme domain,
• a base polymer, and
• a hydrophilic polymer, wherein the hydrophilic polymer comprises from 5 wt. % to 30 wt. % of the enzyme domain, and
• a diffusion resistance domain located more distal to the sensor than the enzyme domain,
• wherein the enzyme stabilizing reagent is selected from the group consisting of cocamidopropyl betaine, oleamidopropyl betaine, lauryl sulfobetaine, myristyl sulfobetaine, betaine (trimethylglycine), octyl betaine, phosphatidylcholine, glycine betaine, poly(carboxybetaine)(pCB), poly(sulfobetaine) (pSB), and precursors or derivatives thereof.