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US 11,994,510 B2Granted
Diagnosis and treatment of Fusariosis and Scedosporiosis
AssigneeThe Brigham and Women's Hospital, Inc.
InventorSophia Koo
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Abstract
Methods for diagnosing, treating, and monitoring the treatment of fusariosis or scedosporiosis are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having fusariosis or scedosporiosis.
Claims10
A method for diagnosing and treating a subject with scedosporiosis, the method comprising:
- obtaining a sample comprising breath of a subject suspected of comprising Scedosporium species fungi isolated from the subject;
- detecting the presence of two, three, or more volatile organic compounds (VOCs) produced by the Scedosporium species in the sample comprising breath from the subject suspected of comprising Scedosporium isolated from the subject, wherein the VOCs are selected from the group consisting of (a) 1H-Indene, 2,3,3a,4-tetrahydro-3,3a,6-trimethyl-1-(1-methylethyl)-, (b) β-guaiene, (c) β-longipinene, (d) β-gurjunene, and (e) isocomene;
- diagnosing the subject as having scedosporiosis when there are two, three or more of the VOCs present in the sample;
- and
- administering an antifungal treatment to the subject diagnosed as having scedosporiosis.
2 more elements
A method of treating a subject who is diagnosed as having an Scedosporium apiospermum, S. prolificans, or S. boydii infection, the method comprising:
- obtaining a sample comprising breath of a subject suspected of comprising Scedosporium apiospermum, S. prolificans, or S. boydii isolated from the subject;
- and:
- diagnosing the subject as having an S. apiospermum infection based on the presence of (a) 1H-Indene, 2,3,3a,4-tetrahydro-3,3a,6-trimethyl-1-(1-methylethyl)-, (b) β-guaiene, (c) (β-longipinene, (d) (β-gurjunene, and (e) isocomene in the sample ;
- diagnosing the subject as having an S. prolificans infection based on the presence of only himachalene and γ-gurjunene in the sample ;
- and
- diagnosing the subject as having an S. boydii infection based on the presence of only γ-gurjunene in the sample;
- and administering an antifungal treatment to the subject who is diagnosed as having the Scedosporium apiospermum, S. prolificans, or S. boydii infection.
4 more elements
Dependencies are inferred from the claim text.