US 11,994,509 B2Granted

Collecting components of a fluid

AssigneeTerumo BCT, Inc.

InventorsMarlene Bainbridge, Todd Curtis Green, Logan Fender

Life of this patent

Estimating the term…

Loading patent…

Abstract

Embodiments are described for separating collecting components from a multi-component fluid such as whole blood. Some embodiments provide for controlling the amount of a component, such as platelets, introduced into a separation chamber to ensure that the density of fluid in the separation chamber does not exceed a particular value. This may provide for collecting purer components. Other embodiments may provide for determining a chamber flow rate based on a concentration of a component in the multi-component fluid, which may then be used to determine a centrifuge speed, to collect purer concentrated components.

Claims20

Dependent claims

A method, comprising:

receiving, by at least one processor, either a first indication of a first collection procedure for collecting a first product from whole blood or a second indication of a second collection procedure for collecting a concentrated product from the whole blood;
when the at least one processor receives the first indication:
receiving, by the at least one processor, first data related to a first amount of a first component in the whole blood from a first source;
rotating a centrifuge at a first centrifuge speed;
introducing the whole blood from the first source into a first separation vessel on the centrifuge at a first flow rate to separate a first composite fluid from the whole blood from the first source;
introducing the first composite fluid, separated from the whole blood from the first source, into a first separation chamber at a first chamber flow rate;
separating the first composite fluid into at least the first component and a second component by subjecting the first composite fluid while in the first separation chamber to a first centrifugal field created by the centrifuge rotating at the first centrifuge speed;
during the separating, maintaining an amount of at least one of the first component of the first composite fluid and the second component of the first composite fluid in the first separation chamber below a predetermined amount;
determining a depletion in the amount of the first component in the whole blood from the first source;
changing, in response to determining the depletion in the amount of the first component in the whole blood from the first source, the first flow rate to introduce the whole blood from the first source into the first separation vessel at a second flow rate;
and
collecting the first component of the first composite fluid in a first storage container to form the first product;
and
when the at least one processor receives the second indication:
receiving, by the at least one processor, the first data;
determining, by the at least one processor, a second chamber flow rate based on the first data;
determining a second centrifuge speed based on the second chamber flow rate;
rotating the centrifuge at the second centrifuge speed;
introducing the whole blood from the first source into the first separation vessel at a third flow rate to separate a second composite fluid from the whole blood from the first source;
introducing the second composite fluid, separated from the whole blood from the first source, into the first separation chamber at the second chamber flow rate;
separating the second composite fluid into at least the first component and the second component by subjecting the second composite fluid while in the first separation chamber to a second centrifugal field created by the centrifuge rotating at the second centrifuge speed;
and
collecting the first component of the second composite fluid in the first storage container to form the concentrated product.

20 more elements

A separation device, comprising:

a centrifuge;
a processor coupled with the centrifuge;
and
a memory coupled with and readable by the processor and storing therein instructions that, when executed by the processor, cause the processor to:
receive either a first indication of a first collection procedure for collecting a first product from whole blood or receive a second indication of a second collection procedure for collecting a concentrated product from the whole blood;
when the processor receives the first indication, the instructions, when executed by the processor, cause the processor to:
receive first data related to a first amount of a first component in the whole blood from a first source;
rotate the centrifuge at a first centrifuge speed;
introduce the whole blood from the first source into a first separation vessel on the centrifuge at a first flow rate to separate a first composite fluid from the whole blood from the first source;
introduce the first composite fluid, separated from the whole blood from the first source, into a first separation chamber at a first chamber flow rate;
separate the first composite fluid into at least the first component and a second component by subjecting the first composite fluid while in the first separation chamber to a first centrifugal field created by the centrifuge rotating at the first centrifuge speed;
during the separating, maintain an amount of at least one of the first component of the first composite fluid and the second component of the first composite fluid in the first separation chamber below a predetermined amount;
determine a depletion in the amount of the first component in the whole blood from the first source;
change, in response to determining the depletion in the amount of the first component in the whole blood from the first source, the first flow rate to introduce the whole blood from the first source into the first separation vessel at a second flow rate;
and
collect the first component of the first composite fluid in a first storage container to form the first product;
and
when the processor receives the second indication, the instructions, when executed by the processor, cause the processor to:
receive the first data;
determine a second chamber flow rate based on the first data;
determine a second centrifuge speed based on the second chamber flow rate;
rotate the centrifuge at the second centrifuge speed;
introduce the whole blood from the first source into the first separation vessel at a third flow rate to separate a second composite fluid from the whole blood from the first source;
introduce the second composite fluid, separated from the whole blood from the first source, into the first separation chamber at the second chamber flow rate;
separate the second composite fluid into at least the first component and the second component by subjecting the second composite fluid while in the first separation chamber to a second centrifugal field created by the centrifuge rotating at the second centrifuge speed;
and
collect the first component of the second composite fluid in the first storage container to form the concentrated product.

24 more elements

A method, comprising:

receiving, by at least one processor, either a first indication of a first collection procedure for collecting a first product from whole blood or a second indication of a second collection procedure for collecting a concentrated product from the whole blood;
when that least one processor receives the first indication:
receiving, by the at least one processor, first data related to a first amount of a first component in the whole blood;
rotating a centrifuge at a first centrifuge speed;
introducing a first portion of the whole blood into a first separation vessel on the centrifuge at a first flow rate to separate a first composite fluid from the first portion of the whole blood;
introducing the first composite fluid, separated from the first portion of the whole blood, into a first separation chamber at a first chamber flow rate;
separating the first composite fluid into at least the first component and a second component by subjecting the first composite fluid while in the first separation chamber to a first centrifugal field created by the centrifuge rotating at the first centrifuge speed;
during the separating, maintaining an amount of at least one of the first component of the first composite fluid and the second component of the first composite fluid in the first separation chamber below a predetermined amount;
determining a depletion in the amount of the first component of the first composite fluid measured in the first portion of the whole blood;
changing, in response to determining the depletion in the amount of the first component measured in the first portion of the whole blood, the first flow rate to introduce the first portion of the whole blood into the first separation vessel at a second flow rate;
and
collecting the first component of the first composite fluid in a first storage container to form the first product;
and
when the at least one processor receives the second indication:
receiving, by the at least one processor, the first data;
determining, by the at least one processor, a second chamber flow rate based on the first data;
determining a second centrifuge speed based on the second chamber flow rate;
rotating the centrifuge at the second centrifuge speed;
introducing a second portion of the whole blood into the first separation vessel at a third flow rate to separate a second composite fluid from the second portion of the whole blood;
introducing the second composite fluid, separated from the second portion of the whole blood, into the first separation chamber at the second chamber flow rate;
separating the second composite fluid into at least the first component and the second component by subjecting the second composite fluid while in the first separation chamber to a second centrifugal field created by the centrifuge rotating at the second centrifuge speed;
and
collecting the first component of the second composite fluid in the first storage container to form the concentrated product.

20 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/745,352Filed 16 May 2022 · continuation
Priority: 13 Oct 2016
Published: US 2022/0276220 A11 Sep 2022
Granted: 28 May 2024
Term ends: Not estimatedThe source records don’t support an estimate.

Classification19 codes

G01N 33/491
Blood: by separating the blood components
A61M 1/3693
Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood…
A61M 1/3696
Using separation based on different densities of components, e.g. centrifuging: with means for adding or withdrawing liquid substances during the…
B01D 21/2472
Discharge mechanisms for the sediments: means for fluidising the sediments, e.g. by jets or mechanical agitators

Family

Application62/407,607Us provisional application · filed 13 Oct 2016
Application15/783,866Parent of this division · filed 13 Oct 2017
Application16/812,582Parent of this continuation · filed 9 Mar 2020
US 10,585,085 B2Parent of this division · filed 10 Mar 2020
US 2022/0276220 A1Pre-grant publication · published 1 Sep 2022
US 11,366,096 B2Parent of this continuation
Application16/812,582Parent of this division
US 2018/0106778 A1Published application
US 2020/0209217 A1Published application
US 11,994,509 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

Building an agent or pulling many patents? Use the API or MCP server instead of scraping pages. Get an API key