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US 11,993,797 B2Granted
Thrombin solution and methods of use thereof
AssigneeOmrix Biopharmaceuticals Ltd.
InventorsRoberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
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Abstract
Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
Claims12
A solid composition consisting of a powder, said powder being obtained by powdering a monolithic block, the composition comprising:
- thrombin;
- a single saccharide or sugar alcohol, said single saccharide or sugar alcohol comprising one member selected from the group consisting of sucrose, maltose, and mannitol, at a concentration of about 19.5% to about 78%, by total weight of the solid composition;
- sodium acetate at a concentration of about 1% to about 20%, by total weight of the solid composition;
- albumin at a concentration of about 2% to about 53%, by total weight of the solid composition;
- calcium chloride at a concentration of about 2.5% to about 31%, by total weight of the solid composition;
- and sodium chloride at a concentration of about 6% to about 45%, by total weight of the solid composition, wherein the solid composition has a water content of less than 3%, by total weight of the solid composition.
3 more elements
Dependencies are inferred from the claim text.