General sequence of chimeric antigen receptor, chimeric antigen receptor and an application thereof

A general sequence of chimeric antigen receptor, wherein a hinge domain comprises a general sequence selected from the group consisting of a hinge domain V-5, a hinge domain V-4-5, a hinge domain V-3-4-5, a hinge domain V-2-3-4-5 or a hinge domain V-1-2-3-4-5;

• wherein
• the nucleotide sequence of the hinge domain V-5 is set forth in SEQ ID NO.1;
• the nucleotide sequence of the hinge domain V-4-5 is set forth in SEQ ID NO.2;
• the nucleotide sequence of the hinge domain V-3-4-5 is set forth in SEQ ID NO.3;
• the nucleotide sequence of the hinge domain V-2-3-4-5 is set forth in SEQ ID NO.4;
• the nucleotide sequence of the hinge domain V-1-2-3-4-5 is set forth in SEQ ID NO.5;
• the nucleotide sequence of the general sequence comprising the hinge domain V-5 is set forth in SEQ ID NO.6;
• the nucleotide sequence of the general sequence comprising the hinge domain V-4-5 is set forth in SEQ ID NO.7;
• the nucleotide sequence of the general sequence comprising the hinge domain V-3-4-5 is set forth in SEQ ID NO.8;
• the nucleotide sequence of the general sequence comprising the hinge domain V-2-3-4-5 is set forth in SEQ ID N0.9;
• and
• the nucleotide sequence of the general sequence comprising the hinge domain V-1-2-3-4-5 is set forth in SEQ ID NO.10.