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US 11,993,661 B2Granted
Constructs targeting prostate-specific membrane antigen (PSMA) and uses thereof
AssigneeEureka Therapeutics, Inc.
InventorsHong Liu, Hongruo Yun, Xiaomei Ge, Zhiyuan Yang, Lianxing Liu, Pengbo Zhang, Yixiang Xu, Shan Li, Lucas Horan
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Abstract
The present application provides constructs comprising an antibody moiety that specifically binds to PSMA (e.g., PSMA expressed on the surface of a cell). Also provided are methods of making and using these constructs.
Claims25
An anti-prostate specific membrane antigen (PSMA) construct comprising an anti-PSMA antibody moiety specifically recognizing an extracellular domain of PSMA comprising the amino acid sequence of SEQ ID NO:
- 44, wherein the anti-PSMA antibody moiety comprises:
- a) a heavy chain variable domain (VH) comprising a heavy chain complementarity determining region (CDR-H) 1 comprising the amino acid sequence of SEQ ID NO:
- 1, a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 3, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 5;
- and a light chain variable domain (VL) comprising a light chain complementarity determining region (CDR-L) 1 comprising the amino acid sequence of SEQ ID NO:
- 7, a CDR-L2 comprising the amino acid sequence GNS, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 9;
- or
- b) a VH comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 2, a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 4, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 6;
- and a VL comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 8, a CDR-L2 comprising the amino acid sequence SNN, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 10.
13 more elements
Dependencies are inferred from the claim text.