PD-1 binding domains

An anti-human PD-1 binding domain comprising a heavy chain variable region, wherein the heavy chain variable region comprises:

• a) heavy chain CDR1 (HCDR1), heavy chain CDR2 (HCDR2), and heavy chain CDR3 (HCDR3), having an amino acid sequence as set forth in SEQ ID NO:
• 22, SEQ ID NO:
• 23 and SEQ ID NO:
• 24, respectively;
• b) heavy chain CDR1 (HCDR1), heavy chain CDR2 (HCDR2), and heavy chain CDR3 (HCDR3), having an amino acid sequence as set forth in SEQ ID NO:
• 25, SEQ ID NO:
• 26, and SEQ ID NO:
• 27, respectively;
• c) heavy chain CDR1 (HCDR1), heavy chain CDR2 (HCDR2), and heavy chain CDR3 (HCDR3), having an amino acid sequence as set forth in SEQ ID NO:
• 28, SEQ ID NO:
• 29, and SEQ ID NO:
• 30, respectively;
• d) heavy chain CDR1 (HCDR1), heavy chain CDR2 (HCDR2), and heavy chain CDR3 (HCDR3), having an amino acid sequence as set forth in SEQ ID NO:
• 31, SEQ ID NO:
• 32, and SEQ ID NO:
• 33, respectively;
• e) heavy chain CDR1 (HCDR1), heavy chain CDR2 (HCDR2), and heavy chain CDR3 (HCDR3), having an amino acid sequence as set forth in SEQ ID NO:
• 34, SEQ ID NO:
• 35, and SEQ ID NO:
• 36, respectively;
• f) heavy chain CDR1 (HCDR1), heavy chain CDR2 (HCDR2), and heavy chain CDR3 (HCDR3), having an amino acid sequence as set forth in SEQ ID NO:
• 37, SEQ ID NO:
• 38, and SEQ ID NO:
• 39, respectively;
• g) heavy chain CDR1 (HCDR1), heavy chain CDR2 (HCDR2), and heavy chain CDR3 (HCDR3), having an amino acid sequence as set forth in SEQ ID NO:
• 40, SEQ ID NO:
• 41, and SEQ ID NO:
• 42, respectively;
• h) heavy chain CDR1 (HCDR1), heavy chain CDR2 (HCDR2), and heavy chain CDR3 (HCDR3), having an amino acid sequence as set forth in SEQ ID NO:
• 43, SEQ ID NO:
• 44, and SEQ ID NO:
• 45, respectively;
• or
• i) heavy chain CDR1 (HCDR1), heavy chain CDR2 (HCDR2), and heavy chain CDR3 (HCDR3), having an amino acid sequence as set forth in SEQ ID NO:
• 46, SEQ ID NO:
• 47, and SEQ ID NO:
• 48, respectively.