Pharmaceutical composition for treatment and prevention of cancer
AssigneeToray Industries, Inc.
InventorsFumiyoshi Okano, Takanori Saito, Takayoshi Ido, Masaki Shimizu
Life of this patent
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Abstract
An antibody or a fragment thereof having immunoreactivity to a polypeptide comprising not less than 7 continuous amino acids in the CD179b protein, which was identified as a cancer antigen protein specifically expressed on the surfaces of cancer cells, can be used as a pharmaceutical composition for therapy and/or prophylaxis of cancer.
Claims5
A method for therapy of human leukemia expressing CD179b protein comprising administering to a human patient having said leukemia an effective amount of an antibody, said antibody having immunoreactivity to a CD179b protein having the amino acid sequence shown in SEQ ID NO:3, wherein the antibody has an Fc effector domain capable of mediating antibody-dependent cell-mediated cytotoxicity (ADCC) by effector cells and complement-dependent cytotoxicity (CDC) against CD179b-expressing cells sufficient to suppress or regress tumors in a living body, and wherein said leukemia is chronic lymphocyte leukemia, wherein said antibody comprises a heavy chain variable region having the amino acid sequence shown in SEQ ID NO:
- 105 and a light chain variable region having the amino acid sequence shown in SEQ ID NO:
- 109.
Dependencies are inferred from the claim text.