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US 11,993,645 B2Granted
Compositions comprising R-Spondin (RSPO) surrogate molecules
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsVincent Christopher Luca, Kenan Christopher Garcia
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Abstract
R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii) a cell targeting domain More specifically, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody fragment, and wherein the cell targeting domain is a cytokine.
Claims10
An RSPO surrogate composition that comprises:
- (i) a specific binding domain for RNF43 or ZNRF3, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody or antigen-binding fragment thereof;
- and
- (ii) a cell-targeting domain, wherein the cell-targeting domain is a cytokine or growth factor that specifically binds a cell surface receptor.
Dependencies are inferred from the claim text.