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US 11,993,638 B2Granted
GM-CSF mimetics and methods of making and using same
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsHuntington Potter, Glenn Simon
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Abstract
The present invention provides novel GM-CSF constructs and methods of using the same. In certain embodiments, the constructs of the invention comprise certain peptide fragments from GM-CSF. In other embodiments, the invention provides certain GM-CSF peptides that act as GM-CSF mimetics.
Claims25
A construct comprising
- M1-L-M2, M2-L-M1, M1-L-M1, M2-L-M2, or consecutively-linked combinations of two or more thereof;
- wherein:
- L is a linker;
- M1 consists of a peptide represented by amino acid residues 11-X of SEQ ID NO:2, wherein X is an integer selected from the group consisting of 23, 24, 25, 26, 27, and 28;
- and
- M2 comprises a peptide represented by amino acid residues X-118 of SEQ ID NO:2, wherein X is an integer selected from the group consisting of 103, 104, 105, 106, 107, 108, 109, 110, and 111.
3 more elements
Dependencies are inferred from the claim text.