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US 11,993,636 B2Granted
Antigenic OspA polypeptides
AssigneeSanofi
InventorsGary J. Nabel, Chih-Jen Wei, Heather Kamp, Ronnie Wei, Kurt Swanson
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Abstract
This disclosure relates to antigenic OspA polypeptides and their use in eliciting antibodies against OspA. Also disclosed are antigenic polypeptides comprising an OspA polypeptide and a ferritin protein.
Claims6
A composition comprising (a) an antigenic outer surface protein A (OspA) serotype 1 polypeptide of Borrelia and (b) a ferritin protein, wherein the OspA serotype 1 polypeptide of Borrelia does not comprise the sequence of SEQ ID NO:
- 77, wherein the OspA serotype 1 polypeptide of Borrelia comprises a sequence with at least 90% identity to the sequence of any one of SEQ ID NOS:
- 1, 3, 4, 53, or 94-102, and wherein the ferritin protein comprises a bullfrog linker that has the sequence of SEQ ID NO:
- 217, and wherein the ferritin protein comprises a sequence having at least 90% identity to SEQ ID NO:
- 90.
1 more element
Dependencies are inferred from the claim text.