Saturated spirocyclics as antiviral agents

A compound represented by Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• A is selected from:
• 1) —R11;
• 2) —OR12;
• 3) —NR17R18;
• and
• 4) —C(R13R14)N(R17R18);
• n is 1, 2, or 3;
• Q1 is selected from:
• 1) —CN;
• 2) —C(O)R15;
• 3) —CH(OH)SO3R16;
• 4) —C(O)NR13R14;
• 5) —C(O)C(O)NR13R14;
• and
• 6) Optionally substituted —C2-C8 alkynyl;
• R1, R2, R3, Q2, and Q3 are each independently selected from:
• 1) Hydrogen;
• 2) Optionally substituted —C1-C8 alkyl;
• 3) Optionally substituted —C2-C8 alkenyl;
• 4) Optionally substituted —C2-C8 alkynyl;
• 5) Optionally substituted —C3-C8 cycloalkyl;
• 6) Optionally substituted 3- to 8-membered heterocycloalkyl;
• 7) Optionally substituted aryl;
• 8) Optionally substituted arylalkyl;
• 9) Optionally substituted heteroaryl;
• and
• 10) Optionally substituted heteroarylalkyl;
• alternatively, R1 and R2 are taken together with the carbon atom to which they are attached to form an optionally substituted 3- to 8-membered carbocyclic ring or an optionally substituted 3- to 8-membered heterocyclic ring;
• alternatively, Q2 and Q3 are taken together with the carbon atom to which they are attached to form an optionally substituted 3- to 8-membered carbocyclic ring or an optionally substituted 3- to 8-membered heterocyclic ring;
• R4 is hydrogen, optionally substituted —C1-C4 alkyl, optionally substituted C2-C4-alkenyl, or optionally substituted —C3-C6 cycloalkyl;
• R11 and R12 are each independently selected from:
• 1) Optionally substituted —C1-C8 alkyl;
• 2) Optionally substituted —C2-C8 alkenyl;
• 3) Optionally substituted —C2-C8 alkynyl;
• 4) Optionally substituted —C3-C8 cycloalkyl;
• 5) Optionally substituted 3- to 8-membered heterocycloalkyl;
• 6) Optionally substituted aryl;
• 7) Optionally substituted arylalkyl;
• 8) Optionally substituted heteroaryl;
• and
• 9) Optionally substituted heteroarylalkyl;
• R13, R14, and R17 each independently selected from:
• 1) Hydrogen;
• 2) Optionally substituted —C1-C8 alkyl;
• 3) Optionally substituted —C2-C8 alkenyl;
• 4) Optionally substituted —C2-C8 alkynyl;
• 5) Optionally substituted —C3-C8 cycloalkyl;
• 6) Optionally substituted 3- to 8-membered heterocycloalkyl;
• 7) Optionally substituted aryl;
• 8) Optionally substituted arylalkyl;
• 9) Optionally substituted heteroaryl;
• and
• 10) Optionally substituted heteroarylalkyl;
• alternatively, R13 and R14 are taken together with the carbon atom to which they are attached to form an optionally substituted 3- to 8-memberedheterocyclic ring;
• R15 is hydrogen, hydroxy, or optionally substituted —C1-C8 alkyl;
• R16 is hydrogen or Na30;
• and
• R18 is selected from:
• —C(O)R11;
• —C(O)OR11;
• —C(O)NR13R14;
• —S(O)2R11;
• Hydrogen;
• Optionally substituted —C1-C8 alkyl;
• Optionally substituted —C2-C8 alkenyl;
• Optionally substituted —C2-C8 alkynyl;
• Optionally substituted —C3-C8 cycloalkyl;
• Optionally substituted 3- to 8-membered heterocycloalkyl;
• Optionally substituted aryl;
• Optionally substituted arylalkyl;
• Optionally substituted heteroaryl;
• and
• Optionally substituted heteroarylalkyl.