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US 11,993,586 B2Granted
Crystalline forms of potassium channel modulators
AssigneeNovartis AG
InventorsGregg F. Keaney, Jun Xu, Wenfeng Xue
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Abstract
Provided herein are crystalline and amorphous forms of a compound having structural formula (1). Also provided are pharmaceutical compositions comprising the crystalline and amorphous forms, methods for their manufacture, and uses thereof for treating a variety of diseases, disorders or conditions, associated with potassium channels.
Claims13
A single crystalline Form B of a compound having structural formula 1:
- wherein the crystalline form is characterized by at least three x-ray powder diffraction peaks at 2 Θ angles selected from 7.2°, 17.7°, 20.1°, 23.3°, and 23.2°.
A single crystalline Form C, single crystalline Form D, single crystalline Form E, or single crystalline Form F of a compound having structural formula 1:
- wherein the single crystalline Form C is characterized by at least three, at least four, five, x-ray powder diffraction peaks at 2 Θ angles selected from 4.2°, 8.5°, 17.00, 20.20, and 21.40;
- wherein the single crystalline Form D is characterized by at least three, at least four, at least five, at least six, or at least seven x-ray powder diffraction peaks at 2 Θ angles selected from 4.90, 99°, 11.10, 17.40, 21.30, 22.20, and 24.8°;
- wherein the single crystalline Form E is characterized by at least three, at least four, at least five, at least six, or at least seven x-ray powder diffraction peaks at 2Θ angles selected from 8.0°, 16.00, 16.80, 17.10, 18.80, 19.30, and 23.4°;
- and wherein the single crystalline Form F is characterized by at least three, at least four, at least five, at least six, or at least seven x-ray powder diffraction peaks at 2 Θ angles selected from 7.1°, 17.90, 18.80, 21.40, 22.10, 24.40, and 28.80.
1 more element
Dependencies are inferred from the claim text.