Pyridazine compounds for inhibiting Nav1.8

A compound of formula (I):

• wherein:
• R1 is selected from the group consisting of:
• wherein:
• n is an integer selected from 0, 1, 2, 3, 4, and 5;
• m is an integer selected from 0, 1, 2, 3, and 4;
• each R11 is independently selected from the group consisting of H, C1-C8 alkyl, halogen, cyano, C1-C8 alkoxyl, C1-C8 haloalkyl, —O—(CH2)p—Ry, wherein p is an integer selected from 0, 1, 2, 3, and 4, and Ry is selected from C3-C10 cycloalkyl and C1-C8 haloalkyl, and —O—CHR12—R13, wherein R12 is H or C1-C8 alkyl and R13 is C3-C8 cycloalkyl;
• R2 is selected from the group consisting of:
• wherein:
• n is an integer selected from 0, 1, 2, 3, 4, and 5;
• m is an integer selected from 0, 1, 2, 3, and 4;
• p is an integer selected from 0, 1, 2, and 3;
• each R6 is independently hydrogen or C1-C8 alkyl;
• each R14 is independently selected from the group consisting of halogen, C1-C8 alkyl, C1-C8 alkoxyl, C1-C8 haloalkyl, cyano, —O—(CH2)p—Ry, wherein p is an integer selected from 0, 1, 2, 3, and 4, and Ry is selected from C3-C10 cycloalkyl and C1-C8 haloalkyl, —S(O)R′, —S(O2)R′, —NR7R8, where R7 and R8 are independently selected from C1-C8 alkyl and C1-C8 haloalkyl, —NR9R10, where R9 and R10 together form a saturated heterocyclic ring selected from the group consisting of piperidinyl, pyrrolidinyl, azetidinyl, morpholinyl, thiomorpholinyl, 1,4-oxazepanyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, and 2-oxa-6-azaspiro[3.3]heptan-6-yl, each of which can optionally substituted with deuterium, C1-C8 alkyl, or halogen;
• and pharmaceutically acceptable salts thereof.